Renacon Pharma

Citrate Concentrate
RENACIT Dry: Citrate Concentrate

    Part-A: Powder
    Part-B: Powder

RENACIT Citrate Concentrate

    Part-A: Solution
    Part-B: Powder


Product Description

RENACIT is Bicarbonate Hemodialysis Concentrate which contains Sodium Citrate as buffering agent replacing significant amount of Acetate, normally present as buffer. The quantity of Sodium Citrate is very low as compared to that needed for systemic anti-coagulation hence its anti--coagulatory effect is only in extra-corporeal circulation.

RENACIT Part-A is available in solution form & Part-B in powder form. RENACIT DRY is available in powder form (Part-A & Part-B).
Advantages

Compared with traditional Hemodialysis Concentrates, "RENACIT Citrate Concentrate" has the following benefits:

    Reduces Heparin need in dialysis patients (upto 40%)
    Increases dialysis dose Kt/V (>1.2) and URR (>70%)
    Significantly reduces clotting in case of Heparin-free Hemodialysis
    Better Kt/V in case of Dialyzer Reuse due to better clearing of fibres
    No of Dialyzer Re-use increases significantly (60-100%)
    Does not cause Thrombocytopenia
    No Heparin Antibodies
    Reduces cost of Heparin
    Significant reduction in bleeding episodes if Heparin is eliminated or reduced
    No Heparin-related complications viz Osteoporosis, Pruritis, disturbed Lipid Metabolism
    Significantly less or no clotting in patients with frequent dialyzer clotting
    Elimination of Acetate-related complications (present as buffer in Concentrates)
    Anti-oxidative effects
    Improved acid-base status
    Reduced inflammation
    Reduction of Pre-dialytic Beta-2-Microglobulin levels
    Improved tolerance to treatment
    Heparin-induced Myeloperoxidase release causes atherosclerosis propagation not present with Citrate concentrate
    Can be used in Liver Failure patients undergoing Hemodialysis

Indications

    Routine Hemodialysis due to its advantages
    Active Bleeding employing Heparin-free hemodialysis
    Suspected bleeding or risk of bleeding
    Disturbed clotting profile
    Absolute or relative contra-indication of Heparin
    Frequent Dialyzer clotting
    Heparin Allergies
    Low Platelet count
    Targeting of better Kt/V with Dialyzer Re-use & increase in number of reuses
    Pre-and Post-surgical patients
    Patients with gastro-intestinal bleeding or active ulcers
    Patients with Hemorrhagic Retinopathies
    Patients with Acetate-related complications like frequent episodes of hypotension, arrhythmias, nausea, etc.
    Old, malnourished patients or those getting Hemodialysis for several years more prone to Acetate toxicity
    Patients with Heparin-related side-effects viz pruritis, osteoporosis, accelerated atherosclerosis, etc.
    Hemodialysis in Liver failure patients with disturbed bleeding/clotting profile